Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 …

…, K Nakamura, Y Oshima, K Hosaka, Y Kubohara

文献索引：Gokan, Naomi; Kikuchi, Haruhisa; Nakamura, Koji; Oshima, Yoshiteru; Hosaka, Kohei; Kubohara, Yuzuru Biochemical Pharmacology, 2005 , vol. 70, # 5 p. 676 - 685

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被引用次数: 41

摘要

The differentiation-inducing factor-1 (DIF-1) is a lipophilic signal molecule (chlorinated alkylphenone) that induces stalk-cell differentiation in the cellular slime mould Dictyostelium discoideum. It has also been shown that DIF-1 and its derivative (DIF-3) suppress cell growth in mammalian tumor cells. In the present study, in order to assess the chemical structure–effect relationship of DIF derivatives and to develop useful agents for the study ...