Deuterium was effectively introduced into the title sugar (1a) at C-1, C-3, C-5, and C-6 to afford 1, 5-anhydro-D-[1-2 H 1],-[3-2 H],-[5-2 H],-[1-2 H 2],-[6-2 H 2], and-[5, 6-2 H 3] glucitols respectively as primary targets for a basic study of the unknown metabolism of 1a, which had been suggested to be a candidate of metabolic indexes for insulin-dependent diabetes mellitus.