Biochemistry

Identification of structural–kinetic and structural–thermodynamic relationships for thrombin inhibitors

J Winquist, S Geschwindner, Y Xue, L Gustavsson…

文献索引：Nilsson, Mikael; Haemaelaeinen, Markku; Ivarsson, Maria; Gottfries, Johan; Xue, Yafeng; Hansson, Sebastian; Isaksson, Roland; Fex, Tomas Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2708 - 2715

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被引用次数: 14

摘要

To improve our understanding of drug–target interactions, we explored the effect of introducing substituted amine residues with increased chain length in the P3 residue of the thrombin inhibitor melagatran. Inhibition, kinetic, and thermodynamic data obtained via