Synthesis of 3H??labeled 2??hydroxy??N??[(1, 3, 3??trimethyl??[4, 5, 6??3H] cyclohexyl) methyl]??5??azidobenzamide, a photoaffinity analog of an influenza fusion inhibitor
…, H Morimoto, BC Pearce, P Williams…
文献索引：Dischino, Douglas D.; Cianci, Christopher; Krystal, Mark; Meanwell, Nicholas A.; Morimoto, Hiromi; Pearce, Bradley C.; Williams, Philip; Yu, Kuo-Long Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 965 - 974
Abstract Synthesis of 3 H-labeled 2-hydroxy-N-[(1, 3, 3-trimethyl-[4, 5, 6-3 H] cyclohexyl) methyl]-5-azidobenzamide, a photoaffinity analog of an influenza fusion inhibitor, is reported. Tritiation of a mixture of N-(t-butoxycarbonyl)-1, 3, 3-trimethylcyclohex-4 (or 5)- enylmethylamine via T 2 and Pd/C, followed by coupling of the deprotected tritiated amine with acetyl 5-azidosalicylic acid chloride yielded the penultimate product. Subsequent ...
