Synthesis of N??alkyl derivatives of 4??(2′??aminoethyl) indole

JG Cannon, BJ Demopoulos

文献索引：Cannon, Joseph G.; Demopoulos, Basil J. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1195 - 1199

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被引用次数: 9

摘要

Abstract N-Substituted 4-(2′-aminoethyl) indoles are attainable in good yields from indole- 4-acetic acid (2). Several methods of preparation for 2 were tried or considered. A new sequence involving Arndt-Eistert homologation of indole-4-carboxylic acid has been devised, which is no more laborious than a literature homologation sequence involving indole-4-acetonitrile, and which provides somewhat better overall yields than the literature ...