New derivatizing agents for amino acids and peptides. 1. Facile synthesis of N-substituted 1-cyanobenz [f] isoindoles and their spectroscopic properties

RG Carlson, K Srinivasachar, RS Givens…

文献索引：Carlson, R. G.; Srinivasachar, K.; Givens, R. S.; Matuszewski, B. K. Journal of Organic Chemistry, 1986 , vol. 51, # 21 p. 3978 - 3983

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被引用次数: 97

摘要

2, 3-Naphthalenedicarboxaldehyde (NDA) is shown to be a very useful reagent for the derivatization of primary amines, amino acids, and small peptides. The reaction of these amino compounds with NDA and cyanide ion produces highly fluorescent 2-substituted 1- cyanobenz [flisoindoles that are relatively stable. The physical and fluorescent properties of a variety of 1, 2-disubstituted benz [flisoindoles are presented.