A convenient approach for the preparation of (1S, 3′ R, 4′ S, 5′ S, 6′ R)-5-chloro-6-[(4- ethylphenyl) methyl]-3′, 4′, 5′, 6′-tetrahydro-6′-(hydroxymethyl)-spiro [isobenzofuran- 1 (3H), 2′-[2H] pyran]-3′, 4′, 5′-triol is developed. The targeted compound was synthesized from 2-bromo-4-methylbenzoic acid in nine steps and the isomers of undesired ortho-products were avoided during the preparation.
