Tetrahedron Letters

Iron (III) tosylate catalyzed synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones/thiones via the Biginelli reaction

JT Starcevich, TJ Laughlin, RS Mohan

文献索引：Starcevich, Jacob T.; Laughlin, Thomas J.; Mohan, Ram S. Tetrahedron Letters, 2013 , vol. 54, # 8 p. 983 - 985

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被引用次数: 34

摘要

The synthesis of dihydropyrimidinones and dihydropyrimidine thiones has attracted interest due to their biological activities. A common method for their synthesis is the Biginelli reaction, which is a one-pot condensation of an aryl aldehyde, urea (or thiourea), and ethyl acetoacetate. The Biginelli reaction is typically catalyzed by a Brønsted or Lewis acid. However, many of these catalysts such as BF3· Et2O and AlCl3 are corrosive and/or toxic. ...