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Studies on Ca2+ channel antagonists. A 2-diazo-3, 3, 3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe

LJ Theodore, WL Nelson, B Dave…

文献索引:Theodore; Nelson; Dave; Giacomini Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 873 - 877

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被引用次数: 4

摘要

Because structure-activity relationship studies on analogues of the phenylalkylamine Ca2+ channel blocker verapamil (1) have shown that a great variety of small structural changes, including changes in the aromatic rings, may be made in these molecules while they still retain high potency and because the 2-diazo-3, 3, 3-trifluoropropionyl substituent has provided useful photoaffinity probes in other systems, lb'* the incorporation of this ...