Journal of medicinal chemistry

Activity of acyclic 6-(phenylselenenyl) pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes

NM Goudgaon, RF Schinazi

文献索引：Goudgaon, Naganna M.; Schinazi, Raymond F. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3305 - 3309

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被引用次数: 65

摘要

Several 6-phenylselenenyl-substituted acyclouridine derivatives were prepared for evaluation as antiviral agents. Lithiation of the tert-butyldimethylsilyl-protected acyclonucleosides 4a-f with lithium diisopropylamide at-78" C, followed by reaction with diphenyl diselenide as an electrophile, and subsequent removal of the protecting group with tetra n-butylammonium fluoride gave 1-[(2-hydroxyethoxy) methyl]-6-(phenylselenenyl) ...