Tetrahedron: Asymmetry

An efficient and general enantioselective synthesis of some isoxazole-containing analogues of the neuroexcitant glutamic acid

H Pajouhesh, K Curry

文献索引：Pajouhesh, Hassan; Curry, Kenneth Tetrahedron Asymmetry, 1998 , vol. 9, # 16 p. 2757 - 2760

全文：HTML全文

被引用次数: 7

摘要

Isoxazole amino acids are an important class of neuroexcitant which are difficult to prepare in enantiopure form. Diastereoselective alkylation of the enantiomerically pure glycine derivative, tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (Boc- BMI) with 4-bromomethyl-2-methoxymethyl-5-methylisoxazolin-5-one 5 or 5-bromomethyl-4- bromo-3-methoxyisoxazole, gives intermediates which under mild hydrolysis conditions ...