Synthesis and 5-Hydroxytryptamine (5-HT) activity of 2, 3, 4, 4a-Tetrahydro-1H-pyrazino [1, 2-a] quinoxalin-5-(6H) ones and 2, 3, 4, 4a, 5, 6-Hexahydro-1H-pyrazino [1, …

…, S Rosenzweig-Lipson, S Sukoff, Y Zhang

文献索引：Welmaker, Gregory S.; Nelson, James A.; Sabalski, Joan E.; Sabb, Annmarie L.; Potoski, John R.; Graziano, Denise; Kagan, Michael; Coupet, Joseph; Dunlop, John; Mazandarani, Hossein; Rosenzweig-Lipson, Sharon; Sukoff, Stacey; Zhang, Yingxin Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1991 - 1994

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被引用次数: 38

摘要

A series of 2, 3, 4, 4a-tetrahydro-1H-pyrazino [1, 2-a] quinoxalin-5-(6H) ones and 2, 3, 4, 4a, 5, 6-hexahydro-1H-pyrazino [1, 2-a] quinoxalines was shown to exhibit 5-HT2C agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague–Dawley rats with ED50 values of 2 mg/kg (ip) and 10 mg/kg (po).