Trypanosoma cruzi: Activities of lapachol and α-and β-lapachone derivatives against epimastigote and trypomastigote forms

…, M Orellana, U Kemmerling, J Ferreira, JD Maya…

文献索引：Salas, Cristian; Tapia, Ricardo A.; Ciudad, Karina; Armstrong, Veronica; Orellana, Myriam; Kemmerling, Ulrike; Ferreira, Jorge; Maya, Juan Diego; Morello, Antonio Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 2 p. 668 - 674

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被引用次数: 74

摘要

Derivatives of natural quinones with biological activities, such as lapachol, α-and β- lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma cruzi cells. All tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity as compared with current trypanocidal drugs, nifurtimox and benznidazole. The results presented here ...