Abstract Representative N-protected 3, 3-difluoroazetidin-2-ones 3 were obtained, either in one step by cycloaddition of zinc enolate 1 derived from ethyl bromodifluoroacetate onto N, N′, N′′-trisubstituted hexahydro-1, 3, 5-triazines 2 (Schiff base trimer) in the case of 3a [N-(p-methoxybenzyl) derivative], or in two steps consisting of a Reformatsky-type reaction for the preparation of N-substituted 3-amino-2, 2-difluoropropanotes 8 followed by N1-C2 ...
