Medicinal Chemistry Research

Antitumor and antileishmanial evaluation of novel heterocycles derived from quinazoline scaffold: a molecular modeling approach

DH Fleita, RM Mohareb, OK Sakka

文献索引：Fleita, Daisy H.; Mohareb, Rafat M.; Sakka, Ola K. Medicinal Chemistry Research, 2013 , vol. 22, # 5 p. 2207 - 2221

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被引用次数: 6

摘要

Abstract Novel thiazole, pyrimidine and benzylidene derivatives derived from quinazoline scaffold have been synthesized. The antitumor evaluation of the newly synthesized products against three cancer cell lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460), and CNS cancer (SF-268) showed that the benzylidene–quinazoline derivative 12a showed remarkable activity against all three cell lines. The thiazolo- ...