Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic Acid-based inhibitors of penicillin-binding proteins.

…, A Zervosen, A Luxen, B Joris, S Gobec

文献索引：Sosic, Izidor; Turk, Samo; Sinreih, Masa; Trost, Nusa; Verlaine, Olivier; Amoroso, Ana; Zervosen, Astrid; Luxen, Andre; Joris, Bernard; Gobec, Stanislav Acta Chimica Slovenica, 2012 , vol. 59, # 2 p. 380 - 388

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被引用次数: 7

摘要

Ab stract Penicillin-binding proteins are a well established, validated and still a very promising target for the design and development of new antibacterial agents. Based on our previous discovery of several noncovalent small-molecule inhibitor hits for resistant PBPs we decided to additionally explore the chemical space around these compounds. In order to clarify their structure-activity relationships for PBP inhibition two new series of compounds ...