Synthesis and hypolipidemic activity of (4-dialkylamino-6-methyl-2-pyrimidinylthio) acethydrazides

PI Vainilavichyus, MMV Burbulene…

文献索引：Vainilavichyus, P. I.; Burbulene, M.-M. V.; Rochka, V.-C. M.; Lautsyuvene, N.-D. I. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 595 - 598 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 931 - 934

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摘要

2-Pyrimidinylthioacethydrazides (V) with a 2, 3-xylidine or p-chlorobenzylamine residue at the 4-position of the pyrimidine ring and a chlorine atom at the 6-position have hypolipidemic activity [I]. To clarify the need for the chlorine atom and the 2, 3-xylidine or p- chlorobenzylamine residue for hypolipidemic activity to be present in the derivatives of (2- pyrimidinylthio) acetic acids, and to search for new hypolipidemic compounds in the ...