The Journal of Organic Chemistry

Template-driven macrolide closures

WH Rastetter, DP Phillion

文献索引：Rastetter, William H.; Phillion, Dennis P. Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3209 - 3214

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被引用次数: 19

摘要

30 crolide 13a, 148% of product (13a) can be recovered after the reaction (48% closure yield). To achieve high-dilution closure of 2a a high-dilution head (pictured in ref 3a) is utilized. The dilution head is a short-path distilling head modified to allow condensed solvent to drain from the filled collection flask back into the distillation pot. In this fashion, solvent is rapidly cycled between the two chambers of the reaction vessel. The templated alkoxide ...