Synthesis of unsymmetrical 1, 4-Bis [(aminoalkyl) amino] anthracene-9, 10-diones for Antineoplastic Evaluation

AP Krapcho, KJ Shaw, JJ Landi Jr…

文献索引：Krapcho; Shaw; Landi Jr.; Phinney Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5253 - 5255

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被引用次数: 18

摘要

This research is patterned after the observation of Griffiths and Hawkid who found that l- methoxyanthracene-9, lO-dione on photolysis in the presence of primary alkylamines afforded the corresponding 1-(alky-lamino) anthracene-9, 1O-diones. It is generally observed in aromatic nucleophilic photochemical substitutions that the position meta to an electron-withdrawing group is activated relative to the ortho or para positions. This is in ...