Potential radiosensitizing agent. 4. 2-Nitroimidazole nucleosides

M Sakaguchi, MW Webb…

文献索引：Sakaguchi, Masakazu; Webb, Matthew W.; Agrawal, Krishna C. Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1339 - 1342

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被引用次数: 15

摘要

A considerable effort has been made recently for the development of effective regimens in radiotherapy that would allow the sensitizaion of the radioresistant hypoxic tumor ce1ls. l Among the chemical sensitizers tested so far from a variety of available nitroheterocyclic compounds, metronidazole, a 5-nitroimidazole derivative, and misonidazole, a 2- nitroimidazole analogue, have been found to be particularly promising in view of their ...