3, 4-Diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2
TD Penning, SW Kramer, LF Lee, PW Collins…
文献索引：Penning, Thomas D.; Kramer, Steven W.; Lee, Len F.; Collins, Paul W.; Koboldt, Carol M.; Seibert, Karen; Veenhuizen, Amy W.; Zhang, Yan Y.; Isakson, Peter C. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2121 - 2124
A series of 3, 4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.
