On the Importance of an Acid Additive in the Synthesis of Pyrido [1, 2??a] benzimidazoles by Direct Copper??Catalyzed Amination

…, WA Herrebout, B Van der Veken…

文献索引：Masters, Kye-Simeon; Rauws, Tom R. M.; Yadav, Ashok K.; Herrebout, Wouter A.; Van Der Veken, Benjamin; Maes, Bert U. W. Chemistry - A European Journal, 2011 , vol. 17, # 23 p. 6315 - 6320

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被引用次数: 80

摘要

PyridoACHTUNGTRENNUNG [1, 2-a] benzimidazoles [1, 2a] are interesting compounds both from the viewpoint of medicinal chemistry [2–7](solubility,[7] DNA intercalation [3]) and materials chemistry [8](fluorescence). Of note among the former is the antibiotic drug Rifaximin,[5] which contains this heteroaromatic core. The classical synthetic approach for the assembly of pyrido-ACHTUNGTRENNUNG [1, 2-a] benzimidazoles is by [3+ 3] ...