Tetrahedron letters

An efficient synthesis of γ-substituted α, β-unsaturated-δ-lactams. Formal synthesis of (±)-protoemetinol

CG Huang, BR Chang, NC Chang

文献索引：Huang, Chang-Gin; Chang, Bo-Rui; Chang, Nein-Chen Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2721 - 2723

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被引用次数: 24

摘要

A great number of piperidine-containing compounds are biologically and medicinally interesting. 1., , , and As a consequence, the development of general methods for the synthesis of piperidine derivatives has been the subject of considerable synthetic efforts. 2 The addition of stabilized anions 3., , and and organocuprates 4., and to γ-substituted α,β-unsaturated δ-lactams 1 has been used as a method for the stereoselective synthesis of cis- and trans-3,4- ...