Optimization of the Conditions for Copper??Mediated N??Arylation of Heteroarylamines

Y Liu, Y Bai, J Zhang, Y Li, J Jiao…

文献索引：Liu, Yifeng; Bai, Yajun; Zhang, Juan; Li, Yangyang; Jiao, Junping; Qi, Xiaoli European Journal of Organic Chemistry, 2007 , # 36 p. 6084 - 6088

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被引用次数: 35

摘要

Abstract Simple and inexpensive copper-mediated N-arylation ofheteroarylamines was achieved by using N, N′-dimethylethylenediamine as a ligand and K 2 CO 3 as a base in dioxane heated at 100 C. In this coupling reaction, the influence of the copper species, ligand, base and solvent was investigated in detail. N-Arylated derivatives of several heteroarylamines were synthesized under optimized reaction conditions, and all the ...