Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2

…, Y Chen, B Calamini, AD Mesecar, MA Lipton

文献索引：St. John, Sarah E.; Jensen, Katherine C.; Kang, Soosung; Chen, Yafang; Calamini, Barbara; Mesecar, Andrew D.; Lipton, Mark A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 6022 - 6037

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被引用次数: 9

摘要

Abstract Resveratrol (3, 5, 4′-trihydroxylstilbene) has been proposed to elicit a variety of positive health effects including protection against cancer and cardiovascular disease. The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, ...