Tetrahedron letters

3-Bromo-2-(tert-butylsulfonyl)-1-propene. A multi-coupling reagent. Part 2.< 1

P Auvray, P Knochel, JF Normant

文献索引：Auvrat, P.; Knochel, P.; Normant, J. F. Tetrahedron Letters, 1985 , vol. 26, # 19 p. 2329 - 2332

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被引用次数: 20

摘要

Abstract 3-bromo-2-(tert-butylsulfonyl)-1-propene 1 reacts in good yields with various electrophiles (aldehydes, ketones, nitriles and alkynes) in the presence of zinc metal to give unsaturated sulfones of type 4. These compounds can further react with soft or hard nucleophiles (alkyl-, vinyl-, aryllithium compounds, a nitroparaffin or dimethylmalonate) to yield highly functionnalized sulfones of type 5 which can be readily transformed into ...