Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production

…, HS Oseni-Olalemi, CE Mordaunt, AJ Vargas…

文献索引：Singh, Mandeep; Schott, Jason T.; Leon, Martin A.; Granata, Robert T.; Dhah, Harkiran K.; Welles, Jason A.; Boyce, Michelle A.; Oseni-Olalemi, Hafeez S.; Mordaunt, Charles E.; Vargas, Anthony J.; Patel, Nilay V.; Maitra, Santanu Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 19 p. 6252 - 6255

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被引用次数: 4

摘要

We have identified a new class of triarylmethyl amine compounds that can inhibit apolipoprotein E (apoE) production. ApoE is a cholesterol-and lipid-carrier protein implicated in aging, atherosclerosis, Alzheimer's Disease (AD), and other neurological and lipid-related disorders. Attenuation of apoE production is generally considered to be of therapeutic value. A majority of the apoE in the brain is produced by astrocytes. Here, we ...