Hydroxylation by cytochrome P-450 and metalloporphyrin models. Evidence for allylic rearrangement

JT Groves, DV Adhyam

文献索引：Groves, John T.; Subramanian, Durga V. Journal of the American Chemical Society, 1984 , vol. 106, # 7 p. 2177 - 2181

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被引用次数: 239

摘要

Abstract: The allylic hydroxylation of 3, 3, 6, 6-tetradeuteriocyclohexene, methylenecyclohexane, and@-pinene has been examined with phenobarbital-induced liver microsomal cytochrome P-450 (P-45OLM2) and with iron porphyrin and chromium porphyrin model systems. Aerobic and peroxide dependent enzymic regimes were investigated with purified P-45OLM2 and with microsomal suspensions. Epoixidation and allylic ...