Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides

D Rennison, D Conole, MD Tingle, J Yang…

文献索引：Rennison, David; Conole, Daniel; Tingle, Malcolm D.; Yang, Junpeng; Eason, Charles T.; Brimble, Margaret A. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6629 - 6635

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被引用次数: 5

摘要

Abstract A number of structural analogues of the known toxicant para-aminopropiophenone (PAPP) have been prepared and evaluated for their capacity to induce methemoglobinemia— with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed for alkyl analogues of PAPP (aminophenones 1–20; compound 6 metHb%= 74.1±2). Besides ...