Bulletin of the Chemical Society of Japan

Studies on antibiotics and related substances. X. Syntheses of some unsaturated ketocarboxylic acids, anti-tumor substances

M Kinoshita, S Umezawa

文献索引：Kinoshita,M.; Umezawa,S. Bulletin of the Chemical Society of Japan, 1960 , vol. 33, p. 1075 - 1080

全文：HTML全文

被引用次数: 9

摘要

1) 2-(Dimethylaminomethyl)-3-ketobutane-1-carboxylic acid hydrochloride (VI) as well as 5- dimethylamino-3-ketopentane-1-carboxylic acid hydrochloride (I) has been obtained from levulinic acid, paraformaldehyde and dimethylamine hydrochloride by means of the Mannich reaction. Thermal degradation of I and VI afforded δ-methylenelevulinic acid (IV) and β-methylenelevulinic acid (VII), respectively. 2) 3-(Dimethylaminomethyl)-4- ...