Towards a total synthesis of the new anticancer agent mensacarcin: Synthesis of the carbocyclic core
LF Tietze, SG Stewart, ME Polomska…
文献索引：Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
Abstract A synthesis of the carbocyclic core associated with the new anticancer agent mensacarcin (1) is reported. The strategy involves the synthesis of several novel highly substituted aromatic compounds, such as 12 and 23. The lithium derivative of 12 readily engages in a nucleophilic addition to benzaldehyde 4 to provide the diphenylcarbinol rac- 15. The analogous benzyl ether rac-16 undergoes an intramolecular Heck reaction to ...
