Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols

…, SK Chauthe, MR Jacob, BL Tekwani, IA Khan…

文献索引：Bharate, Sandip B.; Khan, Shabana I.; Yunus, Nafees A.M.; Chauthe, Siddheshwar K.; Jacob, Melissa R.; Tekwani, Babu L.; Khan, Ikhlas A.; Singh, Inder Pal Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 87 - 96

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被引用次数: 99

摘要

In the present article, we examined the antileishmanial, antimalarial, antibacterial, and antifungal activities of several newly synthesized O-alkylated phloroglucinol compounds (11– 19) which are analogues of the naturally occurring antimalarial compound 1. Analogues 12 and 16 exhibited antileishmanial activity against, Leishmania donovani promastigotes with IC50s of 5.3 and 4.2 μg/mL, respectively. Naturally occurring monomeric formylated ...