Development of 5-[(3-Aminopropyl) phosphinooxy]-2-(hydroxymethyl)-4H-pyran-4-one as a Novel Whitening Agent.
…, HS Baek, KJ Kim, BG Lee, I Chang, HH Kang…
文献索引：Kim, Duck Hee; Hwang, Jae-Sung; Baek, Heung Soo; Kim, Kil-Joong; Lee, Byeong Gon; Chang, Ihseop; Kang, Hak Hee; Lee, Ok Sub Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 2 p. 113 - 116
A stable derivative of kojic acid, 5-[(3-aminopropyl) phosphinooxy]-2-(hydroxymethyl)-4H- pyran-4-one (Kojyl-APPA), was synthesized in good yield. The effects of Kojyl-APPA on tyrosinase activity and melanin synthesis were investigated. Kojyl-APPA showed tyrosinase inhibition effect (30%) in situ, but not in vitro. Kojyl-APPA inhibited tyrosinase activity significantly at 24 h after treatment in normal human melanocytes. It means that Kojyl- ...
