Tetrahedron

Convenient synthesis of melatonin analogues: 2-and 3-substituted-N-acetylindolylalkylamines

VG Nenajdenko, EP Zakurdaev, EV Prusov…

文献索引：Nenajdenko, Valentine G.; Zakurdaev, Eugene P.; Prusov, Eugene V.; Balenkova, Elizabeth S. Tetrahedron, 2004 , vol. 60, # 51 p. 11719 - 11724

全文：HTML全文

被引用次数: 37

摘要

A new method for the synthesis of 2-and 3-substituted indolylalkylamides, derivatives of melatonin, from arylhydrazines and amidoketones by the Fischer reaction was elaborated. The amidoketones can be easily prepared from cyclic imines by reaction with acylpyridinium chloride. This method is a one-step synchronous creation of the selected alkylamide fragment and the indole core. Variation of the arylhydrazines create the desired ...