Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates

…, V Torchilin, C Castro, C Holewa, AE Kallmerten…

文献索引：LaBeaume, Paul; Wager, Krista; Falcone, Danielle; Li, Jane; Torchilin, Vladimir; Castro, Curtis; Holewa, Coleen; Kallmerten, Amy E.; Jones, Graham B. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 17 p. 6292 - 6300

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被引用次数: 12

摘要

Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic ...