Pyridylmethylthio derivatives as VEGF inhibitors: Part 2

H Tajima, T Honda, K Kawashima, Y Sasabuchi…

文献索引：Tajima, Hisashi; Honda, Takahiro; Kawashima, Kenji; Sasabuchi, Yoshimasa; Yamamoto, Minoru; Ban, Masakazu; Okamoto, Kazuyoshi; Inoue, Kenji; Inaba, Takaaki; Takeno, Yuriko; Tsuboi, Takashi; Tonouchi, Asaka; Aono, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1232 - 1235

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被引用次数: 6

摘要

Vascular endothelial growth factor (VEGF) is widely known as a key molecule in angiogenesis, and related to the pathogenesis and/or progression of several diseases such as cancer, rheumatoid arthritis (RA) and age-related macular degeneration (AMD). 1 In recent years, various types of VEGF inhibitors have been launched on the market. For example, Pegaptanib (Macugen) 2 is a VEGF trap, and has been applied for the treatment of AMD. ...