Abstract: Coenzyme Bl2 analogs a-neopentylcobinamide (a-NpCbi+) and a- neopentylcobalamin (a-NpCbl), where the bulky organic ligand is in the ylower*(a) axial ligand position, have been synthesized by reductive alkylation of cyanoaquocobinamide and aquocobalamin, respectively, with neopentyl bromide at-0" C, and characterized by their UV-visible spectra, GC/MS analysis of their anaerobic solid-state pyrolysis products, and ...
