Antitumor amino-substituted pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinolines and pyrido [4, 3-b] carbazole derivatives: synthesis and evaluation of compounds resulting …

C Rivalle, F Wendling, P Tambourin…

文献索引：Rivalle, Christian; Wendling, Francoise; Tambourin, Pierre; Lhoste, Jean-Marc; Bisagni, Emile; Chermann, Jean-Claude Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 181 - 185

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被引用次数: 37

摘要

New modifications of lo-[[3-(diethylamino) propyl] amino]-6-methyl-5H-pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinoline (lb) and 1-[[3-(diethylamino) propyl] amino]-9-methoxy-5, 1l- dimethyl-6H-pyrido [4, 3-b] carbazole (4b), which display important antitumor properties, were performed either on the side chain or on the intercalating heterocycle. Side chains were introduced by direct substitution of the corresponding chloro derivatives and 6-N- ...