Pyridonecarboxylic acids as antibacterial agents. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-1, 8- …
As exemplified by pipemidic acid (1), 2 we showed first that a piperazinyl group was of much importance for the improvement of antibacterial activity and pharmacokinetic properties of a class of pyridonecarboxylic acid antibacterial agents. During the last few years, several analogues having both fluoro and piperazinyl groups in their mole-
