Bioorganic & medicinal chemistry letters

Synthesis and evaluation of novel chloropyrrole molecules designed by molecular hybridization of common pharmacophores as potential antimicrobial agents

RA Rane, VN Telvekar

文献索引：Rane, Rajesh A.; Telvekar, Vikas N. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5681 - 5685

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被引用次数: 41

摘要

In an attempt to identify new potential lead as antimicrobial agent, 31 novel chloropyrrole derivatives of aroyl hydrazones and chalcones incorporating common pharmacophore of pyoluteorin derivatives were synthesized. Antimicrobial activity of the synthesized compounds was evaluated using broth dilution technique. Based on biological evaluation data it was observed that activity increases as the number of chlorines on pyrrole core ...