Tetrahedron

Preparation of optically active cyanohydrins using the (S)-hydroxynitrile lyase from Hevea brasiliensis

M Schmidt, S Hervé, N Klempier, H Griengl

文献索引：Schmidt, Michael; Herve, Stephanie; Klempier, Norbert; Griengl, Herfried Tetrahedron, 1996 , vol. 52, # 23 p. 7833 - 7840

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被引用次数: 102

摘要

Several aliphatic, aromatic and heteroaromatic aldehydes have been converted into the chiral cyanohydrins using the (S)-hydroxynitrile lyase from Hevea brasiliensis. The corresponding cyanohydrins were obtained in moderate to good yield and high enantiomeric excess with the exeption of phenyloxyacetaldehyde, benzyloxyacetaldehyde and the pyrrole-, pyridine-and indolealdehydes investigated. In contrast to previously ...