Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate

…, U Rix, ML Heredia, E Künzel, M Wimberly…

文献索引：Macky, Tamer A.; Oelkers, Carsten; Rix, Uwe; Heredia, Martin L.; Kuenzel, Eva; Wimberly, Mark; Rohrer, Baerbel; Crosson, Craig E.; Rohr, Juergen Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1122 - 1127

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被引用次数: 27

摘要

A novel conjugate of mitomycin C (MMC) and triamcinolone acetonide (TA) was synthesized using glutaric acid as a linker molecule. To determine the rate of hydrolysis, the conjugate was dissolved in aqueous solution and the rate of appearance of free MMC and TA was determined by high-performance liquid chromatography analysis. Antiproliferative activity of the MMC-TA conjugate and parent compounds was assessed using an NIH 3T3 fibroblast ...