An efficient and general method for the Reformatsky-type reaction of chlorodifluoromethyl ketones with carbonyl compounds giving. ALPHA.,. ALPHA.-difluoro-. BETA.- …
M Kuroboshi, T Ishihara
文献索引：Kuroboshi; Ishihara Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 2 p. 428 - 437
Chlorodifluoromethyl ketones CF 2 ClCOR, where R is an alkyl, aryl, and 1-alkynyl group, underwent the Reformatsky-type aldol reaction with a wide variety of aldehydes or ketones in the presence of acid-washed zinc dust and copper (I) chloride or silver acetate to give the corresponding α, α-difluoro-β-hydroxy ketones in good to excellent yields. Specific activation of zinc metal with the metal salt is essential to achieve high efficiency of the reaction, ...
