The Journal of Organic Chemistry

Synthesis of peptides containing S-(N-alkylcarbamoyl) cysteine residues, metabolites of N-alkylformamides in rodents and in humans

MD Threadgill, AP Gledhill

文献索引：Threadgill, Michael D.; Gledhill, Adrian P. Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2940 - 2949

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被引用次数: 48

摘要

Hydrochloride salts of S-(N-methylcarbamoyl), S-(N-ethylcarbamoyl), and S-(Nfl- dimethylcarbamoyl) derivatives of cysteine, N-acetylcysteine, and cysteinylglycine have been prepared. S-(N-Methylcarbamoy1) glutathione hydrochloride has also been synthesized. Protecting groups for amino and carboxylic acid functions were selected for their ability to solubilize the peptides in dichloromethane in which solvent the thiols were ...