Synthesis and Antitumor Activity of Some New 2??Chloroethylnitrosoureas

…, A Papadaki??Valiraki, C Roussakis…

文献索引：Filippatos; Papadaki-Valiraki; Roussakis; Verbist Archiv der Pharmazie, 1993 , vol. 326, # 8 p. 451 - 456

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被引用次数: 14

摘要

Abstract The synthesis of a series of N-(2-chloroethyl)-N′-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N′-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N′-(2-methoxy-9H-xanthen-9- yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.