Synthesis of 2, 4-disubstituted pyrimidines, polypyrimidinediyls, and annulated pyrimidines

…, MJ Cipullo, P Ralli, G Theodoridis

文献索引：Potts, Kevin T.; Cipullo, Michael J.; Ralli, Philip; Theodoridis, George Journal of Organic Chemistry, 1983 , vol. 48, # 25 p. 4841 - 4843

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被引用次数: 21

摘要

Carboxamidines reacted with a-oxoketene dithioacetals in benzene/DMF solution in the presence of sodium hydride, giving 2, 4-disubstituted-6-(methylthio) pyrimidines containing a variety of alkyl, aryl, and heteryl Substituents in the 2 and 4 positions. Bis (a-oxoketene dithioacetals) and 2 equiv of carboxamidine allowed the introduction of several pyrimidine nuclei into the polyheteryl system. Thiourea also reacted with bis (a-oxoketene ...