Anti??anxiety and sedative profile evaluation of imidazo [1, 2??a] pyridine derivatives

M López??Martínez, H Salgado??Zamora…

文献索引：Lopez-Martinez, Margarita; Salgado-Zamora, Hector; San-Juan, Eduardo Ramirez; Zamudio, Sergio; Picazo, Ofir; Campos, Maria Elena; Naranjo-Rodriguez, Elia B. Drug Development Research, 2010 , vol. 71, # 6 p. 371 - 381

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被引用次数: 4

摘要

Abstract Three imidazo [1, 2-a] pyridine-3-nitrosated (L-1, L-2, L-3) and a 3-formyl imidazo [1, 2-a] pyridine thiosemicarbazone (L-4) were synthesized and evaluated for their effects in the elevated plus maze, burying behavior test, rotarod performance, the horizontal wire test, and locomotor activity. L-2 and L-3 increased the percent time spent in the open arms of the plus maze at doses of 1 and 2 mg/kg without modifying the number of total entries. In ...