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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and chemistry of 1, 3-diazabiphenylenes

V Bakthavachalam, M d'Alarcao…

文献索引：Bakthavachalam, Venkatesalu; d'Alarcao, Marc; Leonard, Nelson J. Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 289 - 295

全文：HTML全文

被引用次数: 15

摘要

Two independent syntheses of the 1, 3-diazabiphenylene ring system have been developed. The first of these involves thermal extrusion of nitrogen from a condensed pyridazine precursor, and the second utilizes a diethynylpyrimidine in a cobalt-catalyzed co- oligomerizatioh reaction. The 1, 3-diazabiphenylenes undergo facile transformations to isoquinolines upon treatment with either acid or base. The intermediacy of 1, 3- ...

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~72%

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

查看详情

4-Methoxy-1,3-diazabiphenylene结构式

4-Methoxy-1,3-d...

~%

1,3-dimethoxyisoquinoline结构式

1,3-dimethoxyis...

查看详情

(1,3-dimethoxy-6-trimethylsilylisoquinolin-7-yl)-trimethylsilane结构式

(1,3-dimethoxy-...

~%

1,3-dimethoxyisoquinoline结构式

1,3-dimethoxyis...

查看详情

6,7-Bis(trimethylsilyl)-4-methoxy-1,3-diazabiphenylene结构式

6,7-Bis(trimeth...

~%

1,3-dimethoxyisoquinoline结构式

1,3-dimethoxyis...

查看详情

甲醇结构式

4-Methoxy-1,3-diazabiphenylene结构式

4-Methoxy-1,3-d...

~%

1,3-dimethoxyisoquinoline结构式

1,3-dimethoxyis...

(1,3-dimethoxy-6-trimethylsilylisoquinolin-7-yl)-trimethylsilane结构式

(1,3-dimethoxy-...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

甲酸乙酯结构式

~%

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

查看详情

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

~87%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~%

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

查看详情

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

~13%

2-(2-chloroethynyl)benzonitrile结构式

2-(2-chloroethy...

4-Chloro-1,3-diazabiphenylene结构式

4-Chloro-1,3-di...

2-(2-cyanoethynyl)benzonitrile结构式

2-(2-cyanoethyn...

查看详情

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

~8%

2-(2-chloroethynyl)benzonitrile结构式

2-(2-chloroethy...

4-Chloro-1,3-diazabiphenylene结构式

4-Chloro-1,3-di...

2-(2-cyanoethynyl)benzonitrile结构式

2-(2-cyanoethyn...

查看详情

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

N,N-二(三甲基硅基)乙酰胺结构式

N,N-二(三甲基硅基)乙酰胺

~77%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~%

trimethyl(pyrimido[4,5-c]cinnolin-1-yloxy)silane结构式

trimethyl(pyrim...

查看详情

2-[4-methoxy-6-(2-trimethylsilylethynyl)pyrimidin-5-yl]ethynyl-trimethylsilane结构式

2-[4-methoxy-6-...

~%

4,5-diethynyl-6-methoxypyrimidine结构式

4,5-diethynyl-6...

查看详情

5-(2-bromoethynyl)-4-iodo-6-methoxypyrimidine结构式

5-(2-bromoethyn...

~%

4,5-diethynyl-6-methoxypyrimidine结构式

4,5-diethynyl-6...

查看详情

甲醇结构式

6,7-Bis(trimethylsilyl)-4-methoxy-1,3-diazabiphenylene结构式

6,7-Bis(trimeth...

~73%

(1,3-dimethoxy-6-trimethylsilylisoquinolin-7-yl)-trimethylsilane结构式

(1,3-dimethoxy-...

查看详情

甲醇结构式

4-Methoxy-1,3-diazabiphenylene结构式

4-Methoxy-1,3-d...

~%

1,3-dimethoxyisoquinoline结构式

1,3-dimethoxyis...

(1,3-dimethoxy-6-trimethylsilylisoquinolin-7-yl)-trimethylsilane结构式

(1,3-dimethoxy-...

查看详情

甲醇钠结构式

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

~84%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~%

1-methoxypyrimido[4,5-c]cinnoline结构式

1-methoxypyrimi...

查看详情

甲醇钠结构式

4,6-dichloro-5-(2,2-dibromoethenyl)pyrimidine结构式

4,6-dichloro-5-...

~74%

5-(2-bromoethynyl)-4-chloro-6-methoxypyrimidine结构式

5-(2-bromoethyn...

查看详情

4,6-二氯-5-嘧啶甲醛结构式

4,6-二氯-5-嘧啶甲醛

~%

5-(2-bromoethynyl)-4-chloro-6-methoxypyrimidine结构式

5-(2-bromoethyn...

查看详情

4,6-dichloro-5-(2,2-dibromoethenyl)pyrimidine结构式

4,6-dichloro-5-...

~%

2-(4-chloro-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-chloro-6-m...

查看详情

4,6-二氯-5-嘧啶甲醛结构式

4,6-二氯-5-嘧啶甲醛

~%

2-(4-chloro-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-chloro-6-m...

查看详情

三甲基氯硅烷结构式

三甲基氯硅烷

5-(2-bromoethynyl)-4-chloro-6-methoxypyrimidine结构式

5-(2-bromoethyn...

~%

2-(4-chloro-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-chloro-6-m...

查看详情

三甲基氯硅烷结构式

三甲基氯硅烷

5-(2-bromoethynyl)-4-iodo-6-methoxypyrimidine结构式

5-(2-bromoethyn...

~%

2-(4-bromo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-bromo-6-me...

2-(4-iodo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-iodo-6-met...

查看详情

5-(2,2-dibromoethenyl)-4,6-diiodopyrimidine结构式

5-(2,2-dibromoe...

~%

2-(4-bromo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-bromo-6-me...

查看详情

4,6-二氯-5-嘧啶甲醛结构式

4,6-二氯-5-嘧啶甲醛

~%

2-(4-bromo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-bromo-6-me...

查看详情

三甲基氯硅烷结构式

三甲基氯硅烷

5-(2-bromoethynyl)-4-iodo-6-methoxypyrimidine结构式

5-(2-bromoethyn...

~%

2-(4-bromo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-bromo-6-me...

2-(4-iodo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-iodo-6-met...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~78%

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~80%

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~96%

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

查看详情

4,6-dichloro-5-(2,2-dibromoethenyl)pyrimidine结构式

4,6-dichloro-5-...

~%

2-(4-bromo-6-methoxypyrimidin-5-yl)ethynyl-trimethylsilane结构式

2-(4-bromo-6-me...

查看详情

三甲基氯硅烷结构式

三甲基氯硅烷

5-(2-bromoethynyl)-4-iodo-6-methoxypyrimidine结构式

5-(2-bromoethyn...

三甲基硅基乙炔结构式

三甲基硅基乙炔

~%

2-[4-methoxy-6-(2-trimethylsilylethynyl)pyrimidin-5-yl]ethynyl-trimethylsilane结构式

2-[4-methoxy-6-...

查看详情

甲醇钠结构式

4-Chloro-1,3-diazabiphenylene结构式

4-Chloro-1,3-di...

~83%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

4-Methyl-3-nitrocinnoline结构式

4-Methyl-3-nitr...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

nitroformaldehyde o-acetylphenylhydrazone结构式

nitroformaldehy...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

3-aminocinnoline-4-carboxamide结构式

3-aminocinnolin...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

4H-pyrimido[4,5-c]cinnolin-1-one结构式

4H-pyrimido[4,5...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

3-硝基噌啉-4-甲腈结构式

3-硝基噌啉-4-甲腈

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

3-nitro-4-(nitrosomethylidene)-1H-cinnoline结构式

3-nitro-4-(nitr...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

3-nitrocinnoline-4-carboxamide结构式

3-nitrocinnolin...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

甲醇钠结构式

1-氯-4-氰基异喹啉结构式

1-氯-4-氰基异喹啉

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情

1-chloropyrimido[4,5-c]cinnoline结构式

1-chloropyrimid...

~%

1-methoxyisoquinoline-4-carbonitrile结构式

1-methoxyisoqui...

查看详情