Abstract Baclofen (β-p-chlorophenyl-GABA) is the reference selective agonist for the bicuculline-insensitive GABA B receptor. The search for new compounds having a high affinity for the GABA B receptor is very important to clarify structural requirements. In that sense, we report the synthesis, binding studies and X-ray determinations of various 3- heteroaromatic γ-aminobutyric acids. Biochemical investigations concerning their abilities ...
