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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Total synthesis of tautomycin

M Oikawa, T Ueno, H Oikawa…

文献索引：Oikawa, Masato; Ueno, Tohru; Oikawa, Hideaki; Ichihara, Akitami Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5048 - 5068

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被引用次数: 99

摘要

A convergent stereocontrolled synthesis of the antifungal antibiotic tautomycin, a potent protein phosphatases inhibitor, has been achieved first via key aldol coupling of two large subunits, a righthand C1-CZ1 ketone and a left-hand aldehyde (left from CZZ). The Cl-ClO segment was synthesized through a remote stereochemical control process using a spiroketal template. After joining with the C11-Cls segment, the spiroketal moiety was ...

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~40%

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(2R,3R)-2-Methoxy-4-methyl-1-(phenylthio)-3-pentyl (4Z,3R)-5-(ethoxycarbonyl)-3-((diethyl(1-methylethyl)silyl)oxy)-4-((1,1-dimethylethoxy)carbonyl)-4-hexenoate结构式

(2R,3R)-2-Metho...

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(2R,3R)-2-Methoxy-4-methyl-1-(phenylsulfoxy)-3-pentyl (4Z,3R)-5-(ethoxycarbonyl)-3-((diethyl(1-methylethyl)silyl)oxy)-4-((1,1-dimethylethoxy)carbonyl)-4-hexenoate结构式

(2R,3R)-2-Metho...

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(2S,2(1R,4S,5S),3S,6R,8S,8(3S),9R)-2-(4-((Triethylsilyl)oxy)-1,5-dimethyl-6-oxoheptyl)-3,9-dimethyl-8-(3-methyl-4-pentenyl)-1,7-dioxaspiro(5.5)undecane结构式

(2S,2(1R,4S,5S)...

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[2S,2(1R,4S,5R),3S,6R,8S,8(3S),9R]-2-(4-Hydroxy-1,5-dimethyl-6-heptenyl)-3,9-dimethyl-8-(3-methyl-4-pentenyl)-1,7-dioxaspiro[5.5]undecane结构式

[2S,2(1R,4S,5R)...

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(2R)-2-Methyl-5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-pentanol结构式

(2R)-2-Methyl-5...

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(δR,2R,5S,6S)-6-(Bromomethyl)-δ,5-dimethyltetrahydro-2-pyranylbutyl acetate结构式

(δR,2R,5S,6S)-6...

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Ethyl (4R)-5-(Tetrahydropyran-2-yloxy)-4-methylpentanoate结构式

Ethyl (4R)-5-(T...

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(4R)-((5-(Tetrahydropyran-2-yloxy)-4-methyl-1-pentyl)oxy)(1,1-dimethylethyl)diphenylsilane结构式

(4R)-((5-(Tetra...

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(4R,5S,6S)-((5-(Methoxymethoxy)-4,6-dimethyl-7-octen-1-yl)oxy)(1,1-dimethylethyl)diphenylsilane结构式

(4R,5S,6S)-((5-...

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(4R,5S,6S)-((5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylthio)-1-octyl)oxy)(1,1-dimethylethyl)diphenylsilane结构式

(4R,5S,6S)-((5-...

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(4R,5S,6S)-((5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl)oxy)(1,1-dimethylethyl)diphenylsilane结构式

(4R,5S,6S)-((5-...

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(3S,6S,7R,13S,14S,15R)-18-((tert-butyldiphenylsilyl)oxy)-10-hydroxy-14-(methoxymethoxy)-3,7,13,15-tetramethyl-11-(phenylsulfonyl)octadec-1-en-6-yl 4-nitrobenzoate结构式

(3S,6S,7R,13S,1...

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(2S,3S,6R,11R)-3,11-Dimethyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1,7-dioxaspiro[5.5]undecane结构式

(2S,3S,6R,11R)-...

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(R)-4-((2S,3S,6R,8S,9R)-3,9-dimethyl-8-((S)-3-methylpent-4-en-1-yl)-1,7-dioxaspiro[5.5]undecan-2-yl)pentanal结构式

(R)-4-((2S,3S,6...

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1,1-Dimethylethyl (2R,4R)-2-(3,4-dimethoxyphenyl)-α-oxo-1,3-dioxane-4-acetate结构式

1,1-Dimethyleth...

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(δR,2R,5S,6S)-δ,5-Dimethyl-6-[[(methylsulfonyl)oxy]methyl]tetrahydro-2-pyranylbutyl acetate结构式

(δR,2R,5S,6S)-δ...

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Synthetic studies on tautomycin synthesis of Segment B

[Tsuboi, Katsunori; Ichikawa, Yoshiyasu; Naganawa, Atsushi; Isobe, Minoru; Ubukata, Makoto; Isono, Kiyoshi Tetrahedron, 1997 , vol. 53, # 14 p. 5083 - 5102]

Total Synthesis of the Serine/Threonine-Specific Protein Pho...

[Sheppeck II, James E.; Liu, Wen; Chamberlin, A. Richard Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 387 - 398]

Total Synthesis of the Serine/Threonine-Specific Protein Pho...

[Sheppeck II, James E.; Liu, Wen; Chamberlin, A. Richard Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 387 - 398]

Total Synthesis of the Serine/Threonine-Specific Protein Pho...

[Sheppeck II, James E.; Liu, Wen; Chamberlin, A. Richard Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 387 - 398]

Total Synthesis of the Serine/Threonine-Specific Protein Pho...

[Sheppeck II, James E.; Liu, Wen; Chamberlin, A. Richard Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 387 - 398]